Characteristics of 125I-iodocyanopindolol binding to .BETA.-adrenergic and serotonin-1B receptors of rat brain: Selectivity of .BETA.-adrenergic agents.
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چکیده
منابع مشابه
Characteristics of 1251-lodocyanopindolol Binding to 8-Adrenergic and Serotonin-1B Receptors of Rat Brain: Selectivity of 19-Adrenergic Agents
The present study was designed to examine the specificity of (3-adrenergic antagonists for al-, 192-adrenergic and 5HT1B-serotonergic receptors by the compe titive interaction with 1251-iodocyanopindolol (1251-ICYP) as a radioligand. The 81 -adrenoceptors were preferred by acebutolol, atenolol, betaxolol, practolol, and I-, dl and d-metoprolol, while butoxamine and ICI-118,551 preferred 82-adre...
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T he desensitization (loss of response) and downregulation (loss of receptors) of p-adrenergic receptors (,BAR) have been observed in several cardiac conditions, including certain forms of heart failure and hypertension. The inability of the failing heart to respond to inotropic agents such as catecholamines represents a major clinical problem. The downregulation of 131AR associated with certai...
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288 Communications to the Editor food should interfere with nitrate effects.’ Recent hemodynamic studies in coronary patients indicate increased cardiac and stroke index without changes in mean arterial or pulmonary wedge pressures, which is consistent with the effect of food on STI in our Previous studies of normal conscious dogs were also in agreement, indicating an enhanced inotropic state d...
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288 Communications to the Editor food should interfere with nitrate effects.’ Recent hemodynamic studies in coronary patients indicate increased cardiac and stroke index without changes in mean arterial or pulmonary wedge pressures, which is consistent with the effect of food on STI in our Previous studies of normal conscious dogs were also in agreement, indicating an enhanced inotropic state d...
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ژورنال
عنوان ژورنال: The Japanese Journal of Pharmacology
سال: 1990
ISSN: 0021-5198,1347-3506
DOI: 10.1254/jjp.52.195